Personally a huge fan of the Vega 64. However it really needs tweaking for maximum efficiency.
If you have a Vega 64 budget and power and ease of use are a concern —- 1070ti or 1080.
The Corsair SF450 can push those and a decent CPU.
The "PICKFAST" ebay code today allowed me to get a new Gigabyte 2070 for $450 so I pulled the trigger on that.