I run my 9900K with open wattage but stock clocks. Prime 95 can pull 210 watts all day long. I don't know if there are many stock air coolers that can deal with that heat that also fit in a Cerberus. Maybe the Thermalright Silver Arrow 130? I've got one on a stock 8086K and it does ok. Not an overclocker though.
I've run into an issue with my AIO. My ITX rearmount PSU burned out and I was going to replaced it with an ATX. Unfortunately, the NZXT pumps are too tall per Cerberus.
Additionally, I haven't seen a single RTX 3080 that can fit in 10.6 inches of GPU space I have....
In fact with side vented panel, Noctua C14S is clearly best aircooler you can fit inside Cerberus-X.
Difficulty will come with plain/windowed side panel. In that case, I recommend to switch to either rear 92mm AIO (intake) (Asetek 645LT, Alphacool LT-92 or customed), ideal for gamers as GPU thermals potential is maximum or bigger watercooling but that can downgrade gpu thermals.
In any case, tower cpu cooler are not well suited to standard Cerberus-X with front PSU as there is no full airflow (fresh intake, exhaust). However if you locate PSU somewhere else, well, tower cpu cooler could be interesting...but max cooling is Noctua nh-U9S/D9L or silver arrow 130mm (same perf as noctua)...all noticeably less powerful than Noctua C14S. Fuma-B was a great contender but Fuma 2 is now too tall for it...