It should work if the enclosure and cables fit into an 80 x 80 x 11 mm space. It would negatively affect cooling compared to having two fans, but that is something that is difficult to quantify.
I've just checked the measurements:
Adapter: 57mm x 47mm x 4mm*
Enclosure: 59mm x 48mm x 9.5mm
Would anyone with sata cables, know if it would fit in theory?
The Silverstone SST-CP13 sata cable might work?
*Edit - Turns out that the Sedna adapter in my previous post is too big for the enclsoure. This one from HeroNeo will fit.
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