The size difference is significant especially for a NFC case. The wall/actual power source -> AC-> DC-> internal components is the chain to be resolved. The chassis size of a NFC case would not permit your average PSU or SFX PSU. The S4 chassis is the size of a ream of paper. The Dynamo and HDplex DC units punch far beyond their weight for example, and deserve credit.
I'll be building a skyreach mini with a HDplex 400w and a Dell AC brick myself most likely this year. Now, some see the external brick as a bad or unwanted compromise but I'm fine with it. Heat in particular is lower. It's almost console nostalgic. My MSi 1070 itx might be too long to allow the TBA HDplex AC-DC unless they are slimmer than the out going models.
From previous posts, I think the newer 400W ac dc might be slim enough to fit in a s4 skyreach, so that you can have everything fit in the case. As for dell adapters- I bought one off ebay, and it might be defective, since it causes my PC to randomly restart. Can't wait for the new AC adapter, since I trust HDPlex/G-Unique stuff more than I trust ebay sellers.