So another update. As I have been thinking about this at work today I believe I have come up with a solution to potentially get better airflow, better rigidity from the case, make it cheaper, and allow for better compatibility of pc components. This unfortunately means though that I have to go back to the drawing board...
I believe though that this might be the best way to move forward. I want to go back to my original layout with the radiator mounted on its side. That way it can pull in cool air on one side of the case and exhaust the hot air out the other without ever heating up the 3D printed frame. The difference between my new concept and the original is that the motherboard and GPU will be mounted back to back. This will insulate the two from each other which is another concern I have with prototype one and will allow for a dual slot card in a case that is about 70-80mm in thickness vs the 95mm thickness of the current prototype. It will also allow for the use of standard 6.5mm motherboard standoffs vs the m3 screw approach of prototype one and hide them from view. With the reduction in thickness means a reduction in 3D printed material (in theory) which will decrease the cost of the frame. Now that I know the production capabilities of Ponoko laser cutting I can incorporate more laser cut parts into the design.
I do still plan on redoing the water loop in prototype one just to see what type of performance I can expect from a dual 80mm rad in ideal conditions. If performance still is not great then I might consider trying to incorporate a larger dual 92mm rad into concept 2. More updates to come!