To my knowledge I'm one of the first people to attempt putting a mini itx am4 board in the s4 Mini (Biostar board cooled by a cryorig C7 btw). I'm noticing some compatibility issues that weren't there before. The cooler seems to either be taller than the origional spec, or the AM4 socket is taller than AM3+. When closed up, the fan catches on the side panel. I don't see any obvious solution other than shaving a bit off of the side panel.