@theexplainer See forum post #1958
I aggree on your post, but full-size means cards with a length of 270mm.
What does have this to do with sandwich style? The main disadvantage of sandwich is, that it will not support very thick cards. While a classic pc hardware layout can support it in the same size.
Classic Layout related: The C14 has a lot of clearance and will also work on big I/O shield integrated heatsinks. It is not a complete copy it will give also support for vertical GPU mounting.
C4 Layout related: The newest generation of Asetek based AIOs do not have the problem. PSU cable routing will also work on rotated case. Why do you think it will not work?
Fan grills will not work on a A4-style layout because the mb-tray will be connected in that way to the radiator housing metal parts that you can't fit the grill between them. You second solution can work but I think I have a more elegant one.
The savings come from a reduced length of the case. A reduced in width so only GPUs with reference high will work (nearly every RTX card). And a reduce in height. M1 supports 3 slot card with extra space under it and my design only 2.75 slot cards or 2 slot card with 15mm fan under it. For the AIO question. If you do the math: 149 - 4mm (2xouter panels) - 65mm SFX+ tolerance - 5mm AIO bracket and screws = 75mm free space.
75mm - 30mm radiator - 25mm fan = 20mm for tubing. The tube diameter of AIOs is 10-13mm. So it will easily fit.