@dondan Thanks for going into detail about the A4 vs. C4 decision. I trust you'll bring the topic back up once you're ready to tackle it. It's good to get the info that was in the poll settled first before muddying the waters too much more with more layout questions.
However, if I could briefly address some of the benefits of the C4 layout you identified and perhaps get further clarification as I believe you have been using the prototypes for a while.
1. air noise that will be generated by cables, the middle plate and motherboard that are centered above the fans.
2. losing features like hiding the PSU cable tree
3. how to make the construction stiff enough ( I have to do a drawing to make this more clear)
4. less space for GPU height because of the PCIe female socket site PCB of the riser
5. prevent 8pin CPU power cable not hang inside the fan (this requires a canal under the motherboard that generates more noises)
1. air will be passing by them all the same, and having them centered over the dead spot of a fan might actually be advantageous. You'd be in a better position to test this, however. Additionally, does the rigid riser pose a problem to airflow or create turbulence? Also, I'm glad you brought up the airflow consideration of using the A4 layout with this case, as some users have commented that m.2 temps are a concern in the A4. The C4, no matter what layout it uses, will have two 120mm fans either blowing through or sucking through the case which should mean lower m.2 temps in either layout. Unless I'm mistaken about how effective that is in lowering m.2 temps while in the A4 layout.
2. Personally, I like the challenge of making cable routing look good, and think introducing structured cable routing in a case where every millimeter counts to be wasted space and material, but I do concede that it would be a stand-out feature for some. Certainly few sff cases offer any level of cable organization.
3. Structural rigidity is a noble pursuit as premium parts should feel premium. I look forward to a drawing or modeling on this topic.
4. This is something I had not considered. The A4 layout doesn't have to contend with a 240 aio radiator encroaching on its space. And if we're indeed limited to 2 slots I would hope at least the Evga 1080ti FTW3 card height would be accommodated. Card height is one of the Ncase's biggest weaknesses and I wouldn't want to repeat it in another case.
5. I'm admittedly having a hard time visualizing this issue. Perhaps a picture or diagram about the cable routing would be beneficial.
As always, thanks for taking these and other opinions into consideration. We are all very excited about this case and it shows.