Well, you will always have the tubing bulging out of the case a little but when closing the case, they press on the side panel but not that hard, so you can close the case.
Though, the ram height plays a crucial role in this. When the ram is too high, it will obstruct the tubing and closing the case will be impossible. Thats why low profile ram like the corsair LPX is advised when using the 545LC.
Yeah, I purchased the RAM height for the case itself and not with the AIO included (since it was a included after the build was all planned out). Think I'll swap down to some LPX or HyperX 16GB and pocket some money or add an M.2.