Interesting idea for the Mobo mounting. My only worry would be how secure the mounting points would be in the slots, particularly if they have "vertical" travel which may lead to undo torque on the board should they come loose.
If you look at the image below you can see not all the holes have slots. I tried to make the most common locations holes-only. I'm hoping that will be sufficient for all boards, but let's be honest: I don't have the time or money to test with even 1% of the boards out there so I pretty much have to be hopeful and see how it goes.
Having said that, I think this solution will be a good compromise. I'm even looking at metric standoffs so that I have more options for thumbnuts <- what a funny word.