Excellent. Well, to start things off. What is the most prominent GPU size so far? Don't quote me on this, but it is most likely 2 - 2.5 slot size. I am not saying that 2 slot GPU users will necessary be driven away by a 3 slot capable case. However, I am sure the majority of them will find the extra size unjustified. Specially in this niche market where the whole point is "smaller is better". People here will most likely acquire specific PC parts based on the case as their centre piece for the complete compatibility. Now, is it difficult to make a build aimed at a specific budget and performance level with that 2 slot GPU limitation? To some degree, yes it will be somewhat of a challenge. Albeit, not impossible too.
What I feel like is the best approach would be to create this case with the best performance possible for each part running inside. So, perhaps we stay at the 2 slot size mark (or even 2.5, but I am not very knowledgeable about that) and create a design that would allow the appropriate parts (be it CPU coolers, case fans, etc) that are not overly large of course, and airflow for the best cooling possible. Maybe it could even allow some light overclocking as a result.
I know that my wall of text is probably waste of time because it's, more or less, the standard vision for any case development out there and this all goes without saying. I don't know why I wrote all of this then haha... I am not the best at this, sorry. However, if we can achieve this target. This would set your case aside from most of the others around you who sacrificed performance for size and aesthetics. The key here is balance. Like the perforation design. Circular squares might not be the best looking choice. But it certainly is still is good looking without hampering airflow from entering inside.
Let me know what you think =)