Realistically I think the more likely problem you're going to run into pushing a 1080Ti and say 7700K on this unit is possibly coil whine. The major objective as I understand it to providing the added headroom on this unit was to eliminate the coil whine we saw in the last generation.
As someone who uses a 1080ti and 7700k on this now, yeah there is a lot of coil whine from the HDPlex, and in fact mine didn't survive the exteneded peaks without the performance being permanently diminished (i.e. system shuts off now if I run the card without underclocking first).
When I had the Zotac 1080, I had coil whine from the Zotac board and the HDPlex. I assume the Zotac whined because being smaller with less power stages, it put more stress on the inductors. With the 1080ti FE, I had coil whine just from the HDPlex but not the card.
In any event, anyone planning to use a 1080ti whether mini or otherwise is gonna need a bit more beef than the HDPlex 300w (400w peak) PSU. The guy who makes it is on these forums occasionally right? I think a solid solution would be using the HDPlex 160w DC-DC to drive the motherboard/CPU so that the HDPlex 300w can be completely dedicated to the GPU. I'd like to know if he can confirm whether or not that configuration can work, and whether he's doing any more upgrades to the HDPlex 300w.