looks to me that with a SFX psu , one could squeeze a 240mm rad on the bottom....
then take out the caddy, put the res+pump there, another 240mm on top, and a SLI Matx..... profit.
Personally, I'd move the PSU to above the CPU. There's literally NOTHING on the front panel, so that could be cut out and you could drop a 240mm rad on the front and the top no problem and still fit full-length GPUs.
It would suck to have to pull the PSU every time you wanted to mess with DRAM, or the CPU... and you'd be forced to water cool the CPU at that point, could never air-cool again.