I don't like how the GPU covers the motherboard. Now-adays even the motherboards being manufactured are nice to look at, and I don't think many people would want crap blocking the view of their motherboard. Not to mention, you are making it unnecessarily hard to access motherboard components for trouble shooting and upgrading etc. I like the integration of the space for a 240 radiator, but you should keep the dual chamber layout the A4-SFX had and I would possibly replace my Ncase M1 with this. I am sure other folks would share my criticism.
There isn't really any beneficial attributes this case has over the A4-SFX V2. It still doesn't look as though you could do a custom loop and cool both CPU and GPU because of both getting in the way of each other, but I could be wrong. If you are just planning to use an AIO to cool your CPU, stick with the A4-SFX V2, because it can already do this is is 2 liters smaller.
dondan has explained the reasons. if you want dual chamber layout ,you can chose ghost s1.