Could depend on your setup which you failed to mention. Which GPU cooler type, which CPU cooler, direction of said A9x14, etc.
Personally I haven't compared whether it makes much difference in my setup, but I believe it at least is not hurting. Using a 645LT myself with an EVGA 2070 Super Black. AIO and fan under mobo both set to intake. If I were doing air cooling I'd swap the bottom fans to exhaust most likely.