With a case like this you're probably best, if you want every last drop of efficiency in the air in/out, using a combined custom loop, and a rad at top and bottom.
Also in my recent experience, having the vertical airflow with the classic GPU bottom layout can be bad for chipset/VRM cooling as the airflow can be a bit stagnant above the GPU in that area.
The sandwich approach flips the mobo so the air in at the bottom flows right up into the chipset/VRM area, and then you can have your GPU vertical and being shown off too.
But all considered, does the GPU ever run that hot at the same time as a GPU?
Usually my GPU is being heated a bit by my CPU, or vice versa, but rarely do they both get fully loaded... if you have special case use where they do, then obviously you've got challenges on your hands.
In my DA2 I had GPU on intake at bottom (deshrouded), and CPU above with exhausts at top. GPU would idle at ambient and load was about 60degC.
I've since flipped it due to VRM temps (b550i and that little fan coming on!), and now GPU idles at 10degC over ambient, about 65degC load, but it's quieter now because the CPU is getting cooler air (and runs a smaller fan, 120 vs 140s on GPU).
You can bias which is more important to your workload.