Thanks again for the detailed reply. All of that makes sense. Yeah, the I/O is a bit awkward, I'd definitely prefer it on the bottom for a case this size, but then you'd have to move the fan up and it would be somewhat obstructed by the PSU. I have to say, there's just a bit of awkwardness in the front of this case with the PSU/cables, the fan, and the I/O. Everything gets in the way of everything else a little. Maybe that's just my OCD. The SSDs also block the bottom slots here, so if you have another PCIe card and SSDs, you gotta plug it right under the GPU.
I have to say, for mATX I preferred your earlier designs that were just a traditional layout, 19L or so, space in the front for a 240mm AIO, SFX PSU on the bottom, space for 2 3.5" next to it, full-sized window, that's it. Otherwise, this case is a bit neither here nor there. 16L would be the smallest mATX, but at that point a few L more don't really make that big a difference as it's no longer a super-tiny case anyway and that extra volume is a smaller percentage of the overall, so the utility of it is worth it.
I preferred the previous ITX design, it was like Dan's C4-SFX except with better airflow, dust management, proper GPU orientation, and I/O on the bottom. It was like an M1 except optimized for a window. Really cute-looking too. I get it was more niche, but... it made more sense to me. As does your larger mATX design. Just my 2 cents.