Jup. All you'd need is to drill a 16mm hole where you want the switch to go. There would be two cables included to connect it to the PWR_BTN, HDD_LED and internal USB2 headers of the mainboard. As opposed to most vandal switches you can currently get, there'd be no need to solder. You could also use two of them, one as a power and one as a reset switch, if you were so inclined.