I'd love to see a move to 48V across the board, but to do that would need a completely clean break from ATX, not just in connector form-factor (as with switching to an all-12V design, where passive adapters would allow the use of existing ATX supplies and existing add-in cards) but a total lack of cross-compatibility and backward-compatibility. A one-two-three punch of new motherboards and CPUs, new GPUs, and a new card interface arriving simultaneously could do it, but ALL of those new parts would need to be a significant enough improvement from their predecessors to offset the huge all-at-once capital outlay and justify not being able to 'get by' with incremental upgrades. That would take a lot of industry co-operation to pull off, and even if Intel have the grunt to push out new from-factors for their own parts, that may just end up like BTX if its reliant on independent manufacturers also taking it up. Even the move from AGP to PCIe had some opportunity for cross-compatible parts (e.g. boards with both slots) which would almost certainly not be possible with a move to 48V (having double sets of VRMs would be both extremely expensive, and likely take up too much board area for GPUs and ITX boards).