Looking at this picture specifically and thinking about the Steck and other sandwich style chassis, it would seem to me like having the inlet/outlet ports rotated 90 degrees would be more optimal. In this direction I'm having trouble imagining a tubing layout where the hoses don't interfere with each other, or have to cross "vertically" (out of the boards plane) in order to reach a radiator.
Maybe you've got something up your sleeve; anyway I'm excited to see this project continue.