I'd love to see this be more versatile and smaller and have a design that caters to people that can actually buy these. But all those checkboxes seem to be cleared in the inception stage. I'd love to see mSTX and NUC mounting support, along with possibly storage support (2,5" or 3,5" if possible) for when a GPU wouldn't be used.
Also try to omit fans in the design, the GPU and NUC/mSTX already have fans and there's no need to fill it with even more fans if it's designed around this concept, like the NFC S4 Mini. The ZOTAC GTX 1080 Mini as a max size would allow many GPUs to still be used, like an Radeon Nano, RX460, GTX 1050 Ti, GTX 1060, GTX 1070, GTX 1080 and who knows what AMD will be cooking up. Going full length does have a nice advantage to it but only if it doesn't end up being 12 liters.
Maybe incorporate some kind of grip in the design, something like a inward folded edge on the bottom so you can more easily grab it with one hand. And please called it "Bar". Because RGB lights belong in a strip club.