I think that only the top and bottom panel have to be acrylic since they are more likely to bend.So it's possible to make any of the panels acrylic but not all of them. Just have to modify the file which will not be hard. Even on my original design you can do that for the cover.
If you want to make it fully acrylic just put the panels on the outside of the frame. It will take me a few hours to make it so.