After reading through your replies explaining the thought process and options as well as looking at these, I think the second option is your best bet.View attachment 1560 Top is original
USB will be less affected by eventual obsolescence (For example, I can still use my 2.0 ports for my more basic gear/adapters like keyboards and mice),, so having quick access for things like that will be good.
At the same time, there are plenty of adapters and low profile HDMI 2.1 & DP 1.4 (And eventually DP 2.0) cables that people can use for their setups that many may already have, so letting people go that route will leave people more space to use the rest of their motherboard IO.
The only thing I'd maybe recommend is making sure that the space for cables to bend & be routed under the case is at least 35mm, if not 45-50mm.
I'm barely able to bend my DP 1.4/HDMI 2.1 cable to fit with the 33mm of clearance under the GPU in my Meshlicious, and I literally cut off the stress relief rubber to do so, so I wouldn't go for less space than that.
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