Now, I don't want to be a Nagging Nancy, but I wish the case has just a bit more room at the front for a thicker rad
But having said that - I can definitely imagine replacing my Ncase with this Meshlicious case.
[ Ncase ramblings: The Ncase is great (I have a v6.1) but the side-mounted rad blocks the view on my pretty components. Tempered glass / acrylic with the Ncase is difficult for temps. Just a bottom thin rad is not enough for what I am doing. Dual-rad is nice but not "flashy" enough. Putting the Ncase on tall feet (don't @ me) is imvho f ugly. ]
The 280mm rad (ideally with a custom loop and custom / short cables) will make it easier to cool a 5950X + 3080 Ti (if that ever comes out and I can get one) vs a 240mm AIO Ncase. I would 100% do positive airpressure with Noctua's NF-A12x25 chromax (again, if they ever come out). The mesh keeps at least 'some' dust away while still allowing view of the components (I imagine similar to the FormD T1).
For me personally the Meshlicious is a better compromise between cooling and looks vs the Ncase. Dual-rad Ncase is nice and all but then you have a "black box" that does not show what's inside at all. And a good custom loop with 280mm rad should not be all too much worse vs the dual-rad Ncase of OT.