I have been pondering over such alignment (GPU rotated by 180 degree relative to my current layout), and this has indeed been my initial choice. Comparing options, however, I found that it will result in slightly reduced airflow over the fan as the offset between case and GPU board is slightly smaller in my current alignment (that's assuming use of a cable with a low profile left angle PCIe connector such as the "printed" hdplex pcie 3 - a bit short - or ideally the to-come link-up pcie 4 extreme) when compared to the offset generated by even a cut-down GPU terminal. Of course that comes with its own set of challenges and I will indeed need to machine away quite a lot of the acrylic GPU cover (postig a markup soon...). All that said, rotating the GPU might indeed still be on the cards if the PCIe routing becomes too challenging. Working on a mock-up at the moment.try to rotate the video card 180 degrees. Then part of the plastic can be cut off from the water block and the pci connector will not interfere and the hdmi outputs can be nicely placed on the side of the case
And also turn the radiator with a pump 180 degrees and replace all the fittings with 8 mm and there will be happiness
Re video-out: Plan is to use an internal DP blind plug for headless operation (it's what I do with my current s4 mini) and link a single short DP cable to the ITX/TB3's DP-in at the rear to use the mobo's Thunderbolt port to connect optional additional displays - suffices for the application I plan, and with that in mind the current alignment of the ports works out better - otherwise I'd have a DP connector sticking out at the side...