You can use three monitors with this motherboard by utilizing all three display outputs: DisplayPort 1.2, HDMI 2.0, and Thunderbolt 3. You will need an adapter, such as this one, for the ThunderBolt 3 port if you do not have a monitor that is compatible with this output
There needs to be a third rear bracket type without the PSU cutout. Shift the m-ITX cutout to the far left and use the added space to put in two sideways slots for a full size GPU. Throw in a riser card, too, I guess.
Besides that, it's looking more than solid.