Well I've seen people put 3 radiators in a cerberus x. It is possible to use 2 240 radiators in the case. One on the bottom and one in the front. I think that should be enough to coll both of your components. In that configuration you "should" be able to fit an ATX power supply with the bracket they provide. I think that 480mm of radiator space should be sufficient to cool the components depending on the fans and radiator combo that you go with, think something like the hardware labs nemesis line of radiators. Xtremerigs have done testing on the 280mm version and state the cooling capacity to be ca 380 watts for 10 degree coolant delta at 1850 rpm. The only possible issue I see is that you might have to use slim fans on the front radiator because of the clearance with the gpus. Which, in actuality, might not be a big problem if you are watercooling the cards since that cuts the length of them down.