The PIO (Parts-In-One, basically a DIY All-In-One) motherboard form factor is still fairly rare, but over the last year or so several models from various manufacturers have popped up, at least in pictures and product pages. All the PIO boards so far (that I'm aware of) have used the lower-end Intel chipsets, but ASRock now has an enthusiast option utilizing the Z170 PCH with the new Z170M-PIO2.
Read more here.