@Josh | NFC I decided to email Larry, and ask if any other users had emailed him regarding the issue and he responded back with:
Hi
The design goal for this 300W DCATX is to support i7 plus GTX1070 platform.
GTX1080 is too much for this.From the power consumption maybe not, but the peak could draw around 30A or even 35A on 12V and it will cause coil whine.
Which I can understand. Before the HDplex, I had the 1080 mini hooked up to a Corsair SFX450 and experienced no noticeable coil whine during use. (Playing Hitman). Immediately after swapping out the Corsair for the HDPlex I noticed a whine. Now, it isn't a crazy loud whine, and it might not bother some, but I definitely noticed it. I am very anal about noise, so I will give the 1070 a shot. MSI just released their 1070ITX Aero which has a 0db mode for their fans below 60C. That's a huge plus for me.
On *that* note, I emailed Zotac regarding a bios update for their 1080 mini fan curve. While he told me a 0db on idle is difficult to implement (Bullshit), a update to lower the RPM of the fans on idle is coming soon.