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Remember that not all USBs can be made a portable Windows 10 USB

To avoid unnecessary troubles,the USB drive with USB 3.0/3.1 port (64GB) is the best choice.

[URL unfurl="true"]https://www.uubyte.com/create-a-portable-windows-10-usb.html[/URL]

This is what I learned from this tutorial, there is more to know before you start doing it.

More about Windows To Go from here.

[URL unfurl="true"]https://docs.microsoft.com/en-us/windows/deployment/planning/windows-to-go-overview[/URL]