From what I remember the response to the Losias design basically boiled down to too much cost and too much risk. This was a long time ago so my memory may well be wrong but essentially we were told it would cost a metric fuckton of money (i want to say ~ $400,000 but dont quote me on that) to dev a board and get it certified and whatnot, even starting from an existing design thats already been bought to market and using an existing form factor (mDTX in that instance iirc), & money to actually bring it to market, drum up interest, etc. This is going up against the retentively small, and more importantly, unproven market for such a niche board. Whilst the SFF space is much bigger now that it was then i would hazard a guess the market conditions arent so different that it would rebalance the equation for any vendor w/ a strong enough reputation w/ buyers to actually have a chance. OTOH ASRock are killing it right now, if someone doesnt take a chance to compete & start trying new things soon then they might end up leaving it too late to have a chance.
EDIT: I for one would instabuy an mDTX board w/ dual x8 slots in it and a couple m.2, enough for high speed storage, high speed networking and a decent GPU.