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The PSU fan is likely to intake more than from (edited) the warmed air (passed through the front rad-fan) and exhaust from an cooled display card (exhausting along the top and bottom edges).  This, of course, is not preferred.  Even though I do not think this will trigger the thermal protection of the PSU, I think its fan will spin faster (and more noisy or less quiet).

Example layout:-

[MEDIA=imgur]a/i1sDLBQ[/MEDIA]