I reckon there will be just as many problems.
#1) The entire case relies on the single bottom fan for fresh air intake. Let's say this fan pulls in (ref Noctua NF-A12x25 fan's 102 m3/h or NF-A14 fan's 140 m3/h) 140m3/h. I am using max values to make the picture easier to grab.
As the gap between the display card and the front panel is narrow at 20mm, let's say only 1/3 of these 140 m3/h fresh air will go up the gap to feed the card. This means, about 1/3 x 140 = 47 m3/h will go to the card.
Now take an Asus strix card with three 92mm fans as an example. Each fan pulls in 30 CFM max. Three fans will need 90 CFM (=153 m3/h).
So, the card needs 153 m3/h but only receives 47 m3/h. It is suffocating of fresh air! Even the entire 140 m3/h cannot meet its appetite of 153 m3/h!
#2) Because of the proximity of the CPU intake fan to the display card's exhaust area, most (if not all) of the card's exhaust will be pulled in. So, CPU cooling is not very desirable.
#3) With the PSU flipped upward, the fan should be even more difficult to get fresh air from the bottom case intake fan. I am not sure what you meant by 'PSU so that its intake fan takes some cool air from the back of the case'. If there are openings on the back of the case near the top for fresh air to go in, then hot exhaust from the PSU is going to go back and recirculate. Not good.
As I can see, PSU fan can only possibly pull in some hot exhaust from the display card. Not desirable.
At this configuration, 1/3 of fresh air from case bottom intake fan will go to the display card while the remaining 2/3 will go to the 'main chamber'. A good portion of this 2/3 will go through the CPU intake fan while a smaller portion will be sucked by the rear exhaust fans.
[MEDIA=imgur]a/20QAJfj[/MEDIA]
