I too am concerned about airflow and thermal performance with the new hole grid pattern. The unrestricted airflow was quite a big thing to give up when I switched to the current vent pattern, but I guess I'll never really know how it does until I get the case made and actually have some hardware running inside it.
What do you think, maybe bigger holes? I'm afraid that might make the case look more like a cheese grater like Sean said. 
Thanks, honestly I'm quite surprised with how many people like the old Voronoi vent pattern. It looked a bit too edgy for me. And yeah, the safety barrier is a big reason why I changed to the current circle grid pattern. While the Voronoi pattern allows you to show off your hardware and provides unrestricted airflow, I didn't want someone at a LAN meet to be able to stick their fingers inside the computer and unplug a SATA cable or something.
Ah, they looked sharp because of the bottom corner of the side panels. Thanks for bringing this to my attention. I have them rounded off now. 
I accepted this endeavor as something that would not be cheap. Currently they have me quoted at <$300 for the Voronoi model, which isn't bad at all. Hopefully they show me mercy with the updated hole grid model. Nonetheless, I'm not going to let anything stop me from having my ideas become a reality. I never did. I never will.
Since so many people are requesting this, I've decided to resume tinkering with the inverted layout again. I'll post if anything good comes out of it.