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I'd gather that depends on your case/its cutout, not the board. AFAIK all m.2 slots are spaced the same off the motherboard for clearance/standardization (except for double-stacked ones). IIRC the ATX standard stipulates 9mm from the rear of the motherboard PCB to the motherboard tray. You lose at least a couple of mm from the spacing between the board and the SSD, then the thickness of the SSD comes into play, and I'd be surprised if there was more than 1-2mm left between a bare/heatsinkless rear m.2 and a standard motherboard tray. The part of the SSD on the back of my X370GTN that is outside of the cutout just barely clears the motherboard tray - and that's completely bare.