@Necere I chopped up the bottom my V5 this weekend. I wanted my bottom rad in a different position (as far back and close to the open side as possible) and cut new holes to line up with the fans. Assuming we're past the point of changing anything on V6, maybe this makes for some brainstorming...
Historically, previous Strix "-F" and "-E" mobos were equal price and ~$30 higher than the -I, respectively. The X570-F is $300 and the X570-E is $330. OutletPC is the only site with a listing for the X570-I, and it's $300.
I'm currently running an NCase M1 - 7700K, 1080Ti, custom loop with 2x 240mm rads. I'm thinking I could downsize into an A4 v3 by using the HSLP-48 on my CPU and the 92mm Asetek in a Kraken G10/G12 on my GPU.
If this HSLP-48 comes to fruition, I'll likely be buying an A4-SFX v3 to match it.