Normal
From the looks of it the Intel socket mounting plate adheres to Intel's Keep-Out Zone restrictions, which that motherboard also does. The VRM heatsink might interfere, but it shouldn't if both are designed correctly. It will definitely limit your available mounting orientations though - there's no way you'd be able to have the ports oriented towards the rear I/O. But either upwards or downwards should be fine, and you might even get away with having them pointed towards the RAM slots.