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The new board I'm working on will get rid of the 24 pin ATX and 8 pin EPS in favour of using the Plugless 160W DC as the motherboard part of the solution. What this means is you'll only need to run 4 cables to the motherboard instead of 32 (EPS will still need 8 cables to run from 24 pin header on motherboard to EPS plug though).


Also with this solution you won't need to skimp on the CPU.  Hypothetically if you want to spend the money you could pair it with a 460W 24V switching power supply from Meanwell and have a full 300W to the GPU as well as an additional 75W to the CPU via the PCIe slot. As an added bonus the HDPlex boards are 1-2% more efficient when powered by 24V as opposed to 19V.