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I vote for 280 for two reasons:

1. For custom loops, a single slim 240 isn't enough to dissipate 350W+ of heat at comfortable noise levels. For reference, 5900X + 3080 FE consume ~445W at stock. 280 rads have ~36% more surface area than 240 and can handle such load quite well. I would also make sure that 280 GTS fits in this case which is the best slim 280 rad available.

2. 140mm fans provide more airflow than their 120mm counterparts at the same noise levels (or same airflow at lower noise levels).