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4 x16 slots does absolutely nothing but take up real estate on the board, which is already getting a bit cramped on a μATX board.  Electrically, you are going to have 40 PCI-e lanes and when you try to make lanes split between two connectors, you will need quick switches, adding complexity and degrading signal integrity a little.  A set-up like the X99-M WS should conceivably benchmark (potential cold bug issues aside) better than the Rampage V board for up to three GPUs.