No issues with the SO-DIMM if the pipes are oriented towards the IO-Shield.
(3) 3950X + C14S Build Complete! (NCase) - Anti AIO, details inside! : sffpc (reddit.com)
Some more clarification on T1 v2.0 (And M.2 support for Asus DTX motherboards when using C14s) : FormD (reddit.com)